Annexins are calcium-dependent phospholipid-binding proteins. More than a thousand proteins of the annexin superfamily have been identified in major eukaryotic phyla, but annexins are absent from yeasts and prokaryotes.
The first annexin to be identified was annexin VII (synexin) from the bovine adrenal medulla by creutz and team in 19781.
Annexins are grouped under 5 major classes (A-E), the 12 annexins which are commonly found in vertebrates are classified under annexin A family and named as annexins A1-A13 (or ANXA1-ANXA13), leaving A12 not assigned in the official nomenclature.
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