BAD is a member of the BCl-2 family of proteins and acts to promote apoptosis by forming heterodimers with the survival proteins BCL-2 and BCLXL, thus preventing them from binding with BAX1.
BAD was originally identified in a yeast two hybrid system that was used to screen for BCL-2 interacting proteins1.
BAD belongs to the BH3 sub-family of proteins that also includes other pro-apoptotic proteins; BH3 BID, BIK, BLK, HRK, BNIP3 and BIML2.
clipped from: bio-synthesis.blogspot.com