Meth Coffee, described on the company website as "a volatitherapeutic beverage," is a blend of Arabian and South American coffee beans with "dusting" of yerba mate. Yerba mate is a natural stimulant made from Ilex paraguariensis, a species of holly native to subtropical Argentina, Paraguay, Uruguay and Brazil. Mate is prepared by steeping the dried leaves in hot water; its flavor is compared to that of green tea. Yerba mate is widely available in health food stores.

Mate contains xanthines, which are alkaloids in the same general family as caffeine, theophylline and theobromine (well-known stimulants also found in coffee and chocolate). Mate seems to have physiological effects that are different from coffee; it appears to create a mental state of wakefulness and alertness, but without some of the negative effects of caffeine (like heart palpitations and anxiety).