Demonoid
(a personal favorite of many About.com readers, Demonoid is also a major tracker database that supports thousands of swarms around the globe. Even better, the Demonoid community polices itself by monitoring how much each member actually shares files. ("Leeches" are not tolerated at Demonoid). Note: because new memberships at Demonoid are scarce, you will need to be patient and committed if you wish to join.)
July, 2007: Isohunt has over 450,000 torrents in their database. Also noteworthy: any Isohunt torrent listed as "ISOhunt release" means that it is a file verified by the administrators...a nice feature to help you locate authentic torrents and not fake files. On a sad note: Isohunt is being sued by the Motion Picture Association of America (MPAA) for copyright infringement. If you want to use this tremendous Canadian site, you better use it while you can.